Defective nonoxidative leucine degradation and endogenous leucine flux in cirrhosis during an amino acid infusion
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چکیده
منابع مشابه
Leucine: a key amino acid in ageing-associated sarcopenia?
During ageing, a progressive loss of muscle mass has been well described in both man and rodents. This loss of proteins results from an imbalance between protein synthesis and degradation rates. Although some authors have shown a decrease of myofibrillar protein synthesis rates in human volunteers, this imbalance is not clearly apparent when basal rates of protein turnover are measured. A decre...
متن کاملCloning and characterization of an aromatic amino acid and leucine permease of Penicillium chrysogenum.
The gene encoding the amino acid permease ArlP (Aromatic and leucine Permease) was isolated from the filamentous fungus Penicillium chrysogenum after PCR using degenerated oligonucleotides based on conserved regions of fungal amino acid permeases. The cDNA clone was used for expression of the permease in Saccharomyces cerevisiae M4054, which is defective in the general amino acid permease Gap1....
متن کاملLeucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis.
BACKGROUND The effects of essential amino acid (EAA) supplementation during moderate steady state (ie, endurance) exercise on postexercise skeletal muscle metabolism are not well described, and the potential role of supplemental leucine on muscle protein synthesis (MPS) and associated molecular responses remains to be elucidated. OBJECTIVE This randomized crossover study examined whether EAA ...
متن کاملStimulation of muscle protein synthesis by prolonged parenteral infusion of leucine is dependent on amino acid availability in neonatal pigs.
The postprandial rise in amino acids, particularly leucine, stimulates muscle protein synthesis in neonates. Previously, we showed that a 1-h infusion of leucine increased protein synthesis, but this response was not sustained for 2 h unless the leucine-induced decrease in amino acids was prevented. To determine whether a parenteral leucine infusion can stimulate protein synthesis for a more pr...
متن کاملProtein degradation in human skeletal muscle tissue: the effect of insulin, leucine, amino acids and ions.
1. The protein degradation rate of human skeletal muscle was evaluated in vitro in isolated fibre bundles from the rectus abdominus muscle by measuring the tyrosine released from muscle tissue proteins. Protein metabolism in this semi-intact preparation was compared with that of the intact extensor digitorum longus muscles from rats under the same experimental conditions. 2. Protein balance was...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1998
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.510280526